Language: English » Japanese
RIKEN BSI Home > Research Areas > Advanced Technology Development Core > Gruen Research Unit

Advanced Technology Development Core

Gruen Research Unit

Sonja GRUEN, Ph.D.
Sonja GRUEN, Ph.D.
Unit Leader
E-mailimage
Laboratory websiteLaboratory website
PublicationMain Publications at RIKEN

Research Areas

Higher brain functions are attributed to the cortex, a brain structure composed of a large number of neurons which are highly interconnected. A potential mechanism for neuronal information processing is the coordinated activity of populations of neurons. To approach this level of processing and to study the spatial and temporal scales of neuronal interaction requires to observe large portions of the network simultaneously. Our research focuses on the development of analysis strategies that detect the concerted activity in the brain and enable us to explore the relevance of the observed activity for behavior and cognition.



Research Subjects

  1. Comparison of measures from different spatio-temporal scales
  2. Development of computational methods required to practically compute the relevant measures
  3. Development of statistical tools for data from awake behaving animals

Selected Publications

  1. Grun, S.:
    "Data driven significance estimation for precise spike correlation."
    J Neurophysiol, invited review. J Neurophysiol, doi:10.1152 jn.00093.2008 (in press)
  2. Maldonado, P., Babul, C., Singer, W., Rodriguez, E., Berger, D., and Grun, S.:
    "Synchronization of neuronal responses in primary visual cortex of monkeys viewing natural images."
    J Neurophysiol, 100: 1523-1532, (2008).
  3. Pazienti, A., Maldonado, P., Diesmann, M., and Grun, S.:
    "Effectiveness of systematic spike dithering depends on the precision of cortical synchronization."
    Brain Research, 1225: 39-46, (2008).
  4. Schrader, S., Grun, S., Diesmann, M., and Gerstein, G.:
    "Detecting synfire chain activity using massively parallel spike train recording."
    J Neurophysiol, 100(4): 2165-2176, (2008).
  5. Staude, B., Rotter, S., and Grun, S.:
    "Can spike coordination be differentiated from rate covariation? "
    Neural Computation, 20: 1973-1999, (2008)
  6. Berger, D., Warren, D., Normann, R., Arieli, A., and Grun, S.:
    "Spatially organized spike correlation in cat visual cortex."
    Neurocomputing 70: 2112-2116, (2007).
  7. Denker, M., Roux, S., Timme, M., Riehle, A., and Grun, S.:
    "Phase synchonization between LFP and spiking activity in motor cortex during movement preparation."
    Neurocomputing 70: 2096-2101, (200).
  8. Pazienti, A. and Grun, S.:
    "Robustness of the significance of spike correlation with respect to sorting errors."
    J Comput Neurosci, 21:329-342, (2006).
  9. Grun, S., Diesmann, M., and Aertsen, A.:
    "Unitary Events in multiple single-neuron activity. II. Non-Stationary data."
    Neural Computation, 14(1):81-119, 2002.
  10. Riehle, A., Grun, S., Diesmann, M., and Aertsen, A.:
    "Spike synchronization and rate modulation differentially involved in motor cortical function."
    Science, 278:1950-1953, (1997).

Main Publications at RIKEN


Click here for the full list in a new window